Phables: from fragmented assemblies to high-quality bacteriophage genomes.

ABSTRACT: Microbial communities influence both human health and different environments. Viruses infecting bacteria, known as bacteriophages or phages, play a key role in modulating bacterial communities within environments. High-quality phage genome sequences are essential for advancing our understanding of phage biology, enabling comparative genomics studies, and developing phage-based diagnostic tools. Most available viral identification tools consider individual sequences to determine whether they are of viral origin. As a result of the challenges in viral assembly, fragmentation of genomes can occur, leading to the need for new approaches in viral identification. Therefore, the identification and characterisation of novel phages remain a challenge. We introduce Phables, a new computational metho

SUBMITTER: Mallawaarachchi V 

PROVIDER: S-EPMC10104058 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature