Analysis of the Combined Effect of rs699 and rs5051 on Angiotensinogen Expression and Hypertension.

ABSTRACT: Hypertension (HTN) involves genetic variability in the renin-angiotensin system and characterizing this variability will help advance precision antihypertensive treatments. We previously reported that angiotensinogen (AGT) mRNA is endogenously bound by mir-122-5p and that rs699 A>G significantly decreases reporter mRNA in the functional mirSNP assay PASSPORT-seq. The AGT promoter variant rs5051 C>T is in linkage disequilibrium (LD) with rs699 A>G and increases AGT transcription. We hypothesized that the increased AGT by rs5051 C>T counterbalances AGT decrease by rs699 A>G, and when these variants occur independently, would translate to HTN-related phenotypes. The independent effect of each of these variants is understudied due to their LD, therefore, we u

SUBMITTER: Powell NR 

PROVIDER: S-EPMC10104131 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature