Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion.

ABSTRACT: Consumption of food and water is tightly regulated by the nervous system to maintain internal nutrient homeostasis. Although generally considered independently, interactions between hunger and thirst drives are important to coordinate competing needs. In Drosophila , four neurons called the Interoceptive Subesophageal zone Neurons (ISNs) respond to intrinsic hunger and thirst signals to oppositely regulate sucrose and water ingestion. Here, we investigate the neural circuit downstream of the ISNs to examine how ingestion is regulated based on internal needs. Utilizing the recently available fly brain connectome, we find that the ISNs synapse with a novel cell type Bilateral T-shaped neuron (BiT) that projects to neuroendocrine centers. In vivo neural manipulations revealed th

SUBMITTER: Gonzalez-Segarra AJ 

PROVIDER: S-EPMC10104137 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature