Amine recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor.

ABSTRACT: Bacteria contain many different receptor families that sense different signals permitting an optimal adaptation to the environment. A major limitation in microbiology is the lack of information on the signal molecules that activate receptors. Due to a significant sequence divergence, the signal recognized by sensor domains is only poorly reflected in overall sequence identity. Biogenic amines are of central physiological relevance for microorganisms and serve for example as substrates for aerobic and anaerobic growth, neurotransmitters or osmoprotectants. Based on protein structural information and sequence analysis, we report here the identification of a sequence motif that is specific for amine-sensing dCache sensor domains (dCache_1AM). These domains were identified in more than 13,000

SUBMITTER: Cerna-Vargas JP 

PROVIDER: S-EPMC10104139 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature