Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas reinhardtii.

ABSTRACT: At the core of cilia are microtubules which are important for establishing length and assisting ciliary assembly and disassembly; however, another role for microtubule regulation on ciliogenesis lies outside of the cilium. The microtubule cytoskeleton is a highly dynamic structure which polymerizes and depolymerizes rapidly to assist in cellular processes. These processes have been studied across various organisms with chemical as well as genetic perturbations. However, these have generated conflicting data in terms of the role of cytoplasmic microtubules (CytoMTs) and free tubulin dynamics during ciliogenesis. Here we look at the relationship between ciliogenesis and cytoplasmic microtubule dynamics in Chlamydomonas reinhardtii using chemical and mechanical perturbations. We find t

SUBMITTER: Dougherty LL 

PROVIDER: S-EPMC10104144 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature