Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism.

ABSTRACT:

Introduction

Neuroinflammation and metabolic dysfunction are early alterations in Alzheimer's disease brain that are thought to contribute to disease onset and progression. Glial activation due to protein deposition results in cytokine secretion and shifts in brain metabolism, which have been observed in Alzheimer's disease patients. However, the mechanism by which this immunometabolic feedback loop can injure neurons and cause neurodegeneration remains unclear.

Methods

We used Luminex XMAP technology to quantify hippocampal cytokine concentrations in the 5xFAD mouse model of Alzheimer's disease at milestone timepoints in disease development. We used partial least squares regression to build cytokine signatures predictive of disease progression, as compared to healthy aging

SUBMITTER: Kuhn MK 

PROVIDER: S-EPMC10104145 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature