CD4+ conventional T cells-related genes signature is a prognostic indicator for ovarian cancer.

ABSTRACT:

Introduction

It is believed that ovarian cancer (OC) is the most deadly form of gynecological cancer despite its infrequent occurrence, which makes it one of the most salient public health concerns. Clinical and preclinical studies have revealed that intratumoral CD4+ T cells possess cytotoxic capabilities and were capable of directly killing cancer cells. This study aimed to identify the CD4+ conventional T cells-related genes (CD4TGs) with respect to the prognosis in OC.

Methods

We obtained the transcriptome and clinical data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. CD4TGs were first identified from single-cell datasets, then univariate Cox regression was used to screen prognosis-related genes, LASSO was conducted to remove genes wit

SUBMITTER: Hua T 

PROVIDER: S-EPMC10104164 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature