Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures.

ABSTRACT: The longstanding paradigm is that most bloodstream infections (BSIs) are caused by a single organism. We performed whole genome sequencing of five-to-ten strains from blood culture (BC) bottles in each of ten patients with Candida glabrata BSI. We demonstrated that BCs contained mixed populations of clonal but genetically diverse strains. Genetically distinct strains from two patients exhibited phenotypes that were potentially important during BSIs, including differences in susceptibility to antifungal agents and phagocytosis. In both patients, the clinical microbiology lab recovered a fluconazole-susceptible index strain, but we identified mixed fluconazole-susceptible and â€"resistant populations. Diversity in drug susceptibility was likely clinically relevant, as fluconazole-resi

SUBMITTER: Badrane H 

PROVIDER: S-EPMC10104189 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature