Genetic associations among internalizing and externalizing traits with polysubstance use among young adults.

ABSTRACT: Though most genetic studies of substance use focus on specific substances in isolation or generalized vulnerability across multiple substances, few studies to date focus on the concurrent use of two or more substances within a specified time frame (i.e., polysubstance use; PSU). We evaluated whether distinct genetic factors underlying internalizing and externalizing traits were associated with past 30-day PSU above variance shared across general psychopathology and substance use (SU). Using Genomic Structural Equation Modeling, we constructed theory-driven, multivariate genetic factors of 16 internalizing, externalizing, and SU traits using genome-wide association studies (GWAS) summary statistics. Next, we fit a model with a higher order SU-related psychopathology factor as well as geneti

SUBMITTER: Brick LA 

PROVIDER: S-EPMC10104191 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature