Structural and neurophysiological alterations in Parkinson's disease are aligned with cortical neurochemical systems.

ABSTRACT: Parkinson's disease (PD) affects cortical structures and neurophysiology. How these deviations from normative variants relate to the neurochemical systems of the cortex in a manner corresponding to motor and cognitive symptoms is unknown. We measured cortical thickness and spectral neurophysiological alterations from structural magnetic resonance imaging and task-free magnetoencephalography in patients with idiopathic PD (N _MEG = 79; N _MRI = 65), contrasted with similar data from matched healthy controls (N _MEG = 65; N _MRI = 37). Using linear mixed-effects models and cortical atlases of 19 neurochemical systems, we found that the structural and neurophysiological alterations of PD align with several receptor and transporter systems (acetylcholine

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC10104211 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature