Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.

ABSTRACT: Although young children generally experience mild symptoms following infection with SARS-CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines elicit robust immunoglobulin profiles in children ages 5 years and older, and in adults, corresponding with substantial protection against hospitalizations and severe disease. Whether similar immune responses and humoral protection can be observed in vaccinated infants and young children, who have a developing and vulnerable immune system, remains poorly understood. To study the impact of mRNA vaccination on the humoral immunity of infant, we used a system serology approach to comprehensively profile antibody responses in a cohort of children ages 6 months to 5 years who were vaccinated with the mRNA-1273 COVID-19 vacci

SUBMITTER: Nziza N 

PROVIDER: S-EPMC10104253 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature