3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy.

ABSTRACT: Microinjection protocols are ubiquitous throughout biomedical fields, with hollow microneedle arrays (MNAs) offering distinctive benefits in both research and clinical settings. Unfortunately, manufacturing-associated barriers remain a critical impediment to emerging applications that demand high-density arrays of hollow, high-aspect-ratio microneedles. To address such challenges, here, a hybrid additive manufacturing approach that combines digital light processing (DLP) 3D printing with "ex situ direct laser writing (esDLW)" is presented to enable new classes of MNAs for fluidic microinjections. Experimental results for esDLW-based 3D printing of arrays of high-aspect-ratio microneedles-with 30 μm inner diameters, 50 μm outer diameters, and 550 μm heights, and arrayed with 1

SUBMITTER: Sarker S 

PROVIDER: S-EPMC10104452 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature