Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning.

ABSTRACT: Fear conditioning paradigms are widely used in laboratory settings to discover treatments that enhance memory consolidation and various fear processes (extinction learning, limit return of fear) that are relevant targets of exposure-based therapies. However, traditional lab-based paradigms often use the exact same conditioned stimuli for acquisition and extinction (typically differentiated with a context manipulation), whereas the opposite is true in clinical settings, as exposure therapy rarely (if ever) uses precisely the exact same stimuli from an individual's learning history. Accordingly, this study utilized a novel three-day category-based fear conditioning protocol (that uses categories of non-repeating objects [animals and tools] as conditioned stimuli during fear conditioning and

SUBMITTER: Crombie KM 

PROVIDER: S-EPMC10104454 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature