Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez JA
PROVIDER: S-EPMC10104520 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Sánchez Juan A JA Ingaramo María C MC Gervé María P MP Thomas Maria G MG Boccaccio Graciela L GL Dekanty Andrés A
Proceedings of the National Academy of Sciences of the United States of America 20230404 15
The adipose tissue plays a crucial role in metabolism and physiology, affecting animal lifespan and susceptibility to disease. In this study, we present evidence that adipose Dicer1 (Dcr-1), a conserved type III endoribonuclease involved in miRNA processing, plays a crucial role in the regulation of metabolism, stress resistance, and longevity. Our results indicate that the expression of Dcr-1 in murine 3T3L1 adipocytes is responsive to changes in nutrient levels and is subject to tight regulati ...[more]