Mutant β₁-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.

ABSTRACT: Sleep is essential for our well-being, and chronic sleep deprivation has unfavorable health consequences. We recently demonstrated that two familial natural short sleep (FNSS) mutations, DEC2-P384R and Npsr1-Y206H, are strong genetic modifiers of tauopathy in PS19 mice, a model of tauopathy. To gain more insight into how FNSS variants modify the tau phenotype, we tested the effect of another FNSS gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background. We found that the Adrb1-A187V mutation helped restore rapid eye movement (REM) sleep and alleviated tau aggregation in a sleep-wake center, the locus coeruleus (LC), in PS19 mice. We found that ADRB1⁺ neurons in the central amygdala (CeA) sent project

SUBMITTER: Dong Q 

PROVIDER: S-EPMC10104526 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature