A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains.

ABSTRACT: The early development of aneuploidy from an accidental chromosome missegregation shows contrasting effects. On the one hand, it is associated with significant cellular stress and decreased fitness. On the other hand, it often carries a beneficial effect and provides a quick (but typically transient) solution to external stress. These apparently controversial trends emerge in several experimental contexts, particularly in the presence of duplicated chromosomes. However, we lack a mathematical evolutionary modeling framework that comprehensively captures these trends from the mutational dynamics and the trade-offs involved in the early stages of aneuploidy. Here, focusing on chromosome gains, we address this point by introducing a fitness model where a fitness cost of chromosome duplications

SUBMITTER: Pompei S 

PROVIDER: S-EPMC10104565 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature