Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns.

ABSTRACT: Metabolism is intertwined with various cellular processes, including controlling cell fate, influencing tumorigenesis, participating in stress responses and more. Metabolism is a complex, interdependent network, and local perturbations can have indirect effects that are pervasive across the metabolic network. Current analytical and technical limitations have long created a bottleneck in metabolic data interpretation. To address these shortcomings, we developed Metaboverse, a user-friendly tool to facilitate data exploration and hypothesis generation. Here we introduce algorithms that leverage the metabolic network to extract complex reaction patterns from data. To minimize the impact of missing measurements within the network, we introduce methods that enable pattern recognition across mul

SUBMITTER: Berg JA 

PROVIDER: S-EPMC10104781 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature