A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is a looming public health disaster with limited interventions. Alzheimer's is a complex disease that can present with or without causative mutations and can be accompanied by a range of age-related comorbidities. This diverse presentation makes it difficult to study molecular changes specific to AD. To better understand the molecular signatures of disease we constructed a unique human brain sample cohort inclusive of autosomal dominant AD dementia (ADD), sporadic ADD, and those without dementia but with high AD histopathologic burden, and cognitively normal individuals with no/minimal AD histopathologic burden. All samples are clinically well characterized, and brain tissue was preserved postmortem by rapid autopsy. Samples from four brain regions were processed a

SUBMITTER: Merrihew GE 

PROVIDER: S-EPMC10104800 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature