Aberrant neurophysiological signaling associated with speech impairments in Parkinson's disease.

ABSTRACT: Difficulty producing intelligible speech is a debilitating symptom of Parkinson's disease (PD). Yet, both the robust evaluation of speech impairments and the identification of the affected brain systems are challenging. Using task-free magnetoencephalography, we examine the spectral and spatial definitions of the functional neuropathology underlying reduced speech quality in patients with PD using a new approach to characterize speech impairments and a novel brain-imaging marker. We found that the interactive scoring of speech impairments in PD (N = 59) is reliable across non-expert raters, and better related to the hallmark motor and cognitive impairments of PD than automatically-extracted acoustical features. By relating these speech impairment ratings to neurophysiological deviations fr

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC10104849 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature