Mechanisms of chromosomal instability (CIN) tolerance in aggressive tumors: surviving the genomic chaos.

ABSTRACT: Chromosomal instability (CIN) is a pervasive feature of human cancers involved in tumor initiation and progression and which is found elevated in metastatic stages. CIN can provide survival and adaptation advantages to human cancers. However, too much of a good thing may come at a high cost for tumor cells as excessive degree of CIN-induced chromosomal aberrations can be detrimental for cancer cell survival and proliferation. Thus, aggressive tumors adapt to cope with ongoing CIN and most likely develop unique susceptibilities that can be their Achilles' heel. Determining the differences between the tumor-promoting and tumor-suppressing effects of CIN at the molecular level has become one of the most exciting and challenging aspects in cancer biology. In this review, we summarized the stat

SUBMITTER: Dhital B 

PROVIDER: S-EPMC10104937 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature