Mechanistic modeling of the bioconcentration of (super)hydrophobic compounds in Hyalella azteca.

ABSTRACT: Bioconcentration tests using the freshwater amphipod Hyalella azteca as an alternative to conventional fish tests have recently received much attention. An appropriate computational model of H. azteca could help in understanding the mechanisms behind bioconcentration, in comparison to the fish as test organism. We here present the first mechanistic model for H. azteca that considers the single diffusive processes in the gills and gut. The model matches with the experimental data from the literature quite well when appropriate physiological information is used. The implementation of facilitated transport was essential for modeling. Application of the model for superhydrophobic compounds revealed binding to organic matter and the resulting decrease in bioavailable fraction as the main reason

SUBMITTER: Ebert A 

PROVIDER: S-EPMC10104946 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature