Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders.

ABSTRACT:

Background

Although changes in diffusion characteristics of the brain parenchyma in neurological disorders are widely studied and used in clinical practice, the change in diffusivity in the cerebrospinal fluid (CSF) system is rarely reported. In this study, free water diffusion in the subarachnoid cisterns and ventricles of the rat brain was examined using diffusion magnetic resonance imaging (MRI), and the effects of neurological disorders on diffusivity in CSF system were investigated.

Methods

Diffusion MRI and T₂-weighted images were obtained in the intact rats, 24 h after ischemic stroke, and 50 days after mild traumatic brain injury (mTBI). We conducted the assessment of diffusivity in the rat brain in the subarachnoid cisterns around the midbrain, as well as

SUBMITTER: Tazoe J 

PROVIDER: S-EPMC10104961 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature