Stair climbing, genetic predisposition, and the risk of incident type 2 diabetes: A large population-based prospective cohort study.

ABSTRACT:

Background

Cross-sectional evidence and small-scale trials suggest positive effects of stair climbing on cardiometabolic disease and glucose regulation. However, few studies have examined the long-term association between stair climbing and the incidence of type 2 diabetes (T2D). We aimed to prospectively evaluate the association of stair climbing with T2D and assess modifications by genetic predisposition to T2D.

Methods

We included 451,699 adults (mean age = 56.3 ± 8.1 years, mean ± SD; 55.2% females) without T2D at baseline in the UK Biobank and followed up to March 31, 2021. Stair climbing information was collected through the touchscreen questionnaire. Genetic risk score for T2D consisted of 424 single nucleotide polymorphisms.

Results

During a median follow up o

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10105025 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature