Gut microbiota combined with metabolites reveals unique features of acute myocardial infarction patients different from stable coronary artery disease.

ABSTRACT:

Introduction

Acute myocardial infarction (AMI) accounts for the majority of deaths caused by coronary artery disease (CAD). Early warning of AMI, especially for patients with stable coronary artery disease (sCAD), is urgently needed. Our previous study showed that alterations in the gut microbiota were correlated with CAD severity.

Objectives

Herein, we tried to discover accurate and convenient biomarkers for AMI by combination of gut microbiota and fecal/blood/urinary metabolomics.

Methods

We recruited 190 volunteers including 93 sCAD patients, 49 AMI patients, and 48 subjects with normal coronary artery (NCA), and measured their blood biochemical parameters, 16S rRNA-based gut microbiota and NMR-based fecal/blood/urinary metabolites. We further selected 20 subjects

SUBMITTER: Dong C 

PROVIDER: S-EPMC10105070 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature