Sexual dimorphism in gut microbiota dictates therapeutic efficacy of intravenous immunoglobulin on radiotherapy complications.

ABSTRACT:

Introduction

With the mounting number of cancer survivors, the complications following cancer treatment become novel conundrums and starve for countermeasures. Intravenous immunoglobulin (IVIg) is a purified preparation for immune-deficient and autoimmune conditions.

Objectives

Here, we investigated whether IVIg could be employed to fight against radiation injuries and explored the underlying mechanism.

Methods

Hematopoietic or gastrointestinal (GI) tract toxicity was induced by total body or abdominal local irradiation. High-throughput sequencing was performed to analyze the gut microbiota configurations and gene expression profile of small intestine. The untargeted metabolomics of gut microbiome was assessed by liquid chromatography coupled to tandem mass spectromet

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10105085 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature