Striatal Dopamine Loss in Early Parkinson's Disease: Systematic Review and Novel Analysis of Dopamine Transporter Imaging.

ABSTRACT:

Background

Neuropathological studies, based on small samples, suggest that symptoms of Parkinson's disease (PD) emerge when dopamine/nigrostriatal loss is around 50-80%. Functional neuroimaging can be applied in larger numbers during life, which allows analysis of the extent of dopamine loss more directly.

Objective

To quantify dopamine transporter (DaT) activity by neuroimaging in early PD.

Methods

Systematic review and novel analysis of DaT imaging studies in early PD.

Results

In our systematic review, in 423 unique cases from 27 studies with disease duration of less than 6 years, mean age 58.0 (SD 11.5) years, and mean disease duration 1.8 (SD 1.2) years, striatal loss was 43.5% (95% CI 41.6, 45.4) contralaterally, and 36.0% (95% CI 33.6, 38.3) ipsilaterally

SUBMITTER: Heng N 

PROVIDER: S-EPMC10105104 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature