Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration.

ABSTRACT:

Objectives

Acute lung injury (ALI) poses a serious threat to human health globally, particularly with the Coronavirus 2019 (COVID-19) pandemic. Excessive recruitment and infiltration of neutrophils is the major etiopathogenesis of ALI. Esculin, also known as 6,7-dihydroxycoumarin, is a remarkable compound derived from traditional Chinese medicine Cortex fraxini. Accumulated evidence indicates that esculin has potent anti-inflammatory effects, but its pharmaceutical effect against ALI and potential mechanisms are still unclear.

Methods

This study evaluated the protective effect of esculin against ALI by histopathological observation and biochemical analysis of lung tissues and bronchoalveolar lavage fluid (BALF) in lipopolysaccharide (LPS)-challenged ALI mice in vivo. The eff

SUBMITTER: Ni J 

PROVIDER: S-EPMC10105132 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature