Isolation of new Klebsiella pneumoniae phage PSKP16.

ABSTRACT:

Background and objectives

Klebsiella pneumoniae is a clinically relevant opportunistic pathogen belonging to the Enterobacteriaceae family. It is in the top three bacteria associated with antimicrobial resistance deaths globally, and one of the most dangerous bacteria causing nosocomial infections. Phage therapy offers a potential option for the treatment of drug-resistant bacterial infections.

Materials and methods

Phage PSKP16 was isolated against K. pneumoniae, capsular type K2 (isolated from a wound infection). PSKP16 is a new lytic phage with a Siphovirus-like morphology.

Results

PSKP16 is a linear double stranded DNA phage with a GC content of 50% and genome size of 46,712 bp, for which we predicted 67 ORFs. PSKP16 belongs to the genu

SUBMITTER: Sadeqi S 

PROVIDER: S-EPMC10105268 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature