Anticancer Effect of Fluorouracil and Gum-Based Cerium Oxide Nanoparticles on Human Malignant Colon Carcinoma Cell Line (Caco2).

ABSTRACT:

Objective

We investigated whether co-incubation of 5-FU and gum-based cerium oxide nanoparticles (CeO₂ NPs) would improve half-maximal inhibitory concentration (IC₅₀) and apoptosis in the Caco-2 cancer cell line Materials and Methods: In this experimental study, we synthesized Ceo-2-XG by the nano perception method. X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and vibrating sample magnetometer (VSM) techniques were employed to characterize the synthesized nanoparticles. The Caco-2 cancer cells were cultured and treated with Ceo-2- XG and 5-FU. Cytotoxicity analysis was carried out using MTT assay on Caco-2 cancer cells. CXCR1, CXCR2, CXCL8, BAX, BCL-2, P5

SUBMITTER: Keramati Z 

PROVIDER: S-EPMC10105298 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature