Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood.

ABSTRACT:

Introduction

The impact of maternal coronavirus disease 2019 (COVID-19) infection on fetal health remains to be precisely characterized.

Objectives

Using metabolomic profiling of newborn umbilical cord blood, we aimed to investigate the potential fetal biological consequences of maternal COVID-19 infection.

Methods

Cord blood plasma samples from 23 mild COVID-19 cases (mother infected/newborn negative) and 23 gestational age-matched controls were analyzed using nuclear magnetic spectroscopy and liquid chromatography coupled with mass spectrometry. Metabolite set enrichment analysis (MSEA) was used to evaluate altered biochemical pathways due to COVID-19 intrauterine exposure. Logistic regression models were developed using metabolites to predict intrauterine exposure.

SUBMITTER: Turkoglu O 

PROVIDER: S-EPMC10105349 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature