Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE^-/- mice.

ABSTRACT:

Background

The long-term excessive intake of exogenous cholesterol can lead to abnormally elevated blood lipid levels and induce cardiovascular and cerebrovascular diseases. However, the influence and relevance of exogenous cholesterol on plasma cholesterol components were still unclear, and the influence on intestinal lipid metabolism targets needs to be further explored.

Methods

In vivo, the C57BL/6 + NF group and ApoE^-/- + NF group mice were fed a normal specific pathogen-free (SPF) diet; the ApoE^-/- + HF group mice were fed a high-cholesterol SPF diet. The plasma and jejunum tissue homogenate were obtained for non-targeted lipid metabolomics. The lipid droplets in tissues were observed by transmission electron microscope and oil red O staining. Jeju

SUBMITTER: Yu X 

PROVIDER: S-EPMC10105390 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature