External validation of the QLifetime cardiovascular risk prediction tool: population cohort study.

ABSTRACT: Prediction of lifetime cardiovascular disease (CVD) risk is recommended in many clinical guidelines, but lifetime risk models are rarely externally validated. The aim of this study was to externally validate the QRiskLifetime incident CVD risk prediction tool. Independent external validation of QRiskLifetime using Clinical Practice Research Datalink data, examining discrimination and calibration in the whole population and stratified by age, and reclassification compared to QRISK3. Since lifetime CVD risk is unobservable, performance was evaluated at 10-years' follow-up, and lifetime performance inferred in terms of performance for in the different age-groups from which lifetime predictions are derived. One million, two hundreds sixty thousand and three hundreds twenty nine women and 1,223

SUBMITTER: Livingstone S 

PROVIDER: S-EPMC10105395 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature