Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea.

ABSTRACT:

Background

Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya.

Results

Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the h

SUBMITTER: Liang H 

PROVIDER: S-EPMC10105419 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature