Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β.

ABSTRACT:

Background

Cell adhesion is indispensable for appropriate tissue architecture and function in multicellular organisms. Besides maintaining tissue integrity, cell adhesion molecules, including tight-junction proteins claudins (CLDNs), exhibit the signaling abilities to control a variety of physiological and pathological processes. However, it is still fragmentary how cell adhesion signaling accesses the nucleus and regulates gene expression.

Methods

By generating a number of knockout and rescued human breast cell lines and comparing their phenotypes, we determined whether and how CLDN4 affected breast cancer progression in vitro and in vivo. We also identified by RNA sequencing downstream genes whose expression was altered by CLDN4-adhesion signaling. Additionally, we analyze

SUBMITTER: Murakami-Nishimagi Y 

PROVIDER: S-EPMC10105442 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature