Hepatotoxicity induced by isoniazid in patients with latent tuberculosis infection: a meta-analysis.

ABSTRACT:

Aim

The aim of the present study was to conduct a meta-analysis of the frequency of isoniazid-induced liver injury (INH-ILI) in patients receiving isoniazid (INH) preventative therapy (IPT).

Background

The frequency of hepatotoxicity (drug-induced liver injury: DILI) of antituberculosis drugs has been studied, especially when INH, rifampin, and pyrazinamide are co-administered. However, little is known about the frequency of DILI in patients with latent tuberculosis infection (LTBI), where IPT is indicated.

Methods

We searched PubMed, Google Scholar, and the Cochrane Database of Systematic Reviews for studies reporting the frequency of INH-ILI in patients with IPT using one or more diagnostic indicators included in the criteria of the DILI Expert Working Group.

Res

SUBMITTER: Oscanoa TJ 

PROVIDER: S-EPMC10105504 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature