Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer.

ABSTRACT:

Background

Approximately 10-20% of patients diagnosed with prostate cancer (PCa) evolve into castration-resistant prostate cancer (CRPC), while nearly 90% of patients with metastatic CRPC (mCRPC) exhibit osseous metastases (BM). These BM are intimately correlated with the stability of the tumour microenvironment.

Purpose

This study aspires to uncover the metabolism-related genes and the underlying mechanisms responsible for bone metastatic prostate cancer (BMPCa).

Methods

Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets of PCa and BM were analyzed through R Studio software to identify differentially expressed genes (DEGs). The DEGs underwent functional enrichment via Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO), with k

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10105558 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature