Sex differences in the mediating role of chronic inflammation on the association between social isolation and cognitive functioning among older adults in the United States.

ABSTRACT:

Background

Previous research has reported the association between social isolation and cognitive impairment. However, biological mechanisms underlying this association are understudied. It is also unclear whether there are sex differences in these biological mechanisms.

Objectives

To examine whether chronic inflammation biomarkers are potential mediators of the association between social isolation and cognitive functioning among older men and women.

Methods

Data were the National Health and Nutrition Examination Survey 1999-2002. A total of 2535 older adults aged 60 and older were included. Chronic inflammation was measured by C-reactive protein (CRP), plasma fibrinogen, and serum albumin. Cognitive functioning was assessed by the Digit Symbol Substitution Test (DSST)

SUBMITTER: Qi X 

PROVIDER: S-EPMC10105626 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature