Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank.

ABSTRACT:

Purpose

The composition of thrombi retrieved during endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) may differ depending on their origin. In this study, we investigated the association between thrombus composition and stroke etiology in a large population of patients from the Dutch MR CLEAN Registry treated with EVT in daily clinical practice.

Methods

The thrombi of 332 patients with AIS were histologically analyzed for red blood cells (RBC), fibrin/platelets (F/P), and white blood cells (leukocytes) using a machine learning algorithm. Stroke etiology was assessed using the Trial of Org 10,172 in acute stroke treatment (TOAST) classification.

Results

The thrombi of cardioembolic origin contained less RBC and more F/P

SUBMITTER: Hund HM 

PROVIDER: S-EPMC10105654 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature