Calcineurin-dependent regulation of gap junction conductance and connexin phosphorylation in guinea pig left atrium.

ABSTRACT: Atrial fibrillation (AF) occurs from disordered atrial action potential conduction and is associated with reduced gap junction electrical conductance (G_j). The Ca²⁺ and calmodulin-dependent phosphatase, calcineurin, reduces G_j in ventricular myocardium via a protein phosphatase-1 (PP1)-dependent pathway culminating in phosphorylation of serine368 on connexin43 (pSer368-Cx43). However, characterisation of corresponding pathways in left atrial myocardium, which have a more complex connexin subtype profile, is undefined and was the aim of this study. G_j was measured in guinea-pig left atrium from the frequency-dependent variation of intracellular impedance; intracellular [Ca²⁺], ([Ca²⁺]_i) in low-Na solution was measu

SUBMITTER: Jabr RI 

PROVIDER: S-EPMC10105670 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature