Hyponatremia-related liver steatofibrosis and impaired spermatogenesis: evidence from a mouse model of the syndrome of inappropriate antidiuresis.

ABSTRACT:

Purpose

Hyponatremia is the most frequent electrolytic disorder in clinical practice. In addition to neurological symptoms, hyponatremia, even when mild/moderate and chronic, has been related to other manifestations, such as bone demineralization and increased risk of fractures. To better elucidate tissue alterations associated with reduced serum sodium concentration [Na⁺], we developed an in vivo model of hyponatremia secondary to the Syndrome of Inappropriate Antidiuresis.

Methods and results

Hyponatremia was induced in Foxn1^nu/nu mice by subcutaneous infusion of the vasopressin analog 1-deamino [8-D-arginine] vasopressin (dDAVP) for 14 days via osmotic mini-pumps. Mice in the control group were infused with isotonic saline solution. Serum [Na^+</

SUBMITTER: Marroncini G 

PROVIDER: S-EPMC10105679 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature