Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.

ABSTRACT: Brain aging may accelerate after rodents reach middle age. However, the endogenous mediator that promotes this acceleration is unknown. We predict that the mediator may be expressed after an organism reaches middle age and dysregulates mitochondrial function. In the neurons of wild-type Drosophila (flies), we observed that mitochondria were fragmented in aged flies, and this fragmentation was associated with mitochondrial calcium overload. In a previous study, we found that mitochondrial fragmentation induced by calcium overload was reversed by the loss of Vimar, which forms a complex with Miro. Interestingly, Vimar expression was increased after the flies reached middle age. Overexpression of Vimar in neurons resulted in premature aging and mitochondrial calcium overload. In contrast, dow

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC10105717 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature