Multiparametric dynamic whole-body PSMA PET/CT using [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]PSMA-1007.

ABSTRACT:

Background

Routine prostate-specific membrane antigen (PSMA) positron emission tomography (PET) performed for primary staging or restaging of prostate cancer patients is usually done as a single static image acquisition 60 min after tracer administration. In this study, we employ dynamic whole-body (D-WB) PET imaging to compare the pharmacokinetics of [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]PSMA-1007 in various tissues and lesions, and to assess whether Patlak parametric images are quantitative and improve lesion detection and image readability.

Methods

Twenty male patients with prostate cancer were examined using a D-WB PSMA PET protocol. Ten patients were scanned with [⁶⁸Ga]Ga-PSMA-11 and ten with [¹⁸F]PSMA-1007. Kinetic analyses were made usi

SUBMITTER: Dias AH 

PROVIDER: S-EPMC10105814 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature