Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy.

ABSTRACT:

Background

The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has attracted great attention for its ability to up-regulate innate immune response and thus enhance cancer immunotherapy. However, many STING agonists limit the further advancement of immunotherapy due to weak tumor responsiveness or low activation efficiency. The responsive and effective activation of cGAS-STING signaling in tumors is a highly challenging process.

Methods

In this study, a manganese-based nanoplatform (MPCZ NPs) was constructed that could responsively and efficiently generate more manganese ions (Mn²⁺) and reactive oxygen species (ROS) to activate cGAS-STING signaling pathway. Briefly, mang

SUBMITTER: He Q 

PROVIDER: S-EPMC10105937 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature