Mosquito bites and stage-specific antibody responses against Plasmodium falciparum in southern Ghana.

ABSTRACT:

Background

The human host elicits specific immune responses after exposure to various life stages of the malaria parasite as well as components of mosquito saliva injected into the host during a mosquito bite. This study describes differences in IgG responses against antigens derived from the sporozoite (PfCSP), asexual stage parasite (PfEBA175) and the gametocyte (Pfs230), in addition to an Anopheles gambiae salivary gland antigen (gSG6-P1), in two communities in Ghana with similar blood stage malaria parasite prevalence.

Methods

This study used archived plasma samples collected from an earlier cross-sectional study that enrolled volunteers aged from 6 months to 70 years from Simiw, peri-urban community (N = 347) and Obom, rural community (N = 291). An archived thick and th

SUBMITTER: Kwapong SS 

PROVIDER: S-EPMC10105943 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature