Use of norepinephrine in preterm neonates with dopamine-resistant shock: a retrospective single-centre cross-sectional study.

ABSTRACT:

Background

Norepinephrine (NE) is recommended for children and full-term neonates (born at >37 gestational weeks) with septic shock. Meanwhile, data on the effectiveness of NE in preterm neonates are still limited. This study aimed to evaluate the clinical efficacy of NE in preterm neonates with dopamine-resistant shock compared with that in full-term neonates.

Methods

This was a single-centre, retrospective (January 2010-December 2020) cohort study of neonates with persistent shock despite adequate fluid resuscitation and dopamine or dobutamine administration at ≥10 μg/kg/min. Medical records of neonates treated with NE were retrospectively reviewed to collect respiratory and haemodynamic parameters and results of arterial blood gas (ABG) tests before and 8 hours after NE i

SUBMITTER: Lu P 

PROVIDER: S-EPMC10106054 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature