Association between the volume of fluid resuscitation and mortality modified by disease severity in patients with sepsis in ICU: a retrospective cohort study.

ABSTRACT:

Objective

The important effect modifiers of high disease severity on the relationship between the different volumes of early fluid resuscitation and prognosis in septic patients are unknown. Thus, this study was designed to assess whether the efficacy of different volumes in the early fluid resuscitation treatment of sepsis is affected by disease severity.

Design

Retrospective cohort study.

Setting

Adult intensive care unit (ICU) patients with sepsis from 2001 to 2012 in the MIMIC-III database.

Interventions

The intravenous fluid volume within 6 hours after the sepsis diagnosis serves as the primary exposure. The patients were divided into the standard (≥ 30 mL/kg) and restrict (<30 mL/kg) groups. Disease severity was defined by the sequential organ failure ass

SUBMITTER: Zheng R 

PROVIDER: S-EPMC10106076 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature