Cadmium nitrate and DNA methylation in gastropods: comparison between ovotestis and hepatopancreas.

ABSTRACT: Dietary ingestion is the main route of exposure to hazardous contaminants in land animals. Cadmium, a high-profile toxic metal, affects living systems at different organismal levels, including major storage organs (liver, kidneys), key organs for species survival (gonads), and epigenetic networks regulating gene expression. 5-methylcytosine (5mC) is the most common and best-characterized epigenetic mark among different modified nucleosides in DNA. This important player in methylation-driven gene expression is impacted by cadmium in sentinel terrestrial vertebrates. However, limited information exists regarding its impact on macroinvertebrates, especially land snails commonly used as (eco)toxicological models. We first investigate the methylomic effects of dietary cadmium given as cadmium n

SUBMITTER: Draghici GA 

PROVIDER: S-EPMC10106083 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature