Dataset Information

Real-World Evaluation of Bebtelovimab Effectiveness During the Period of COVID-19 Omicron Variants including BA.4/BA.5.

ABSTRACT:

Objectives

Bebtelovimab is an anti-SARS-CoV-2 monoclonal antibody active against Omicron lineage variants authorized to treat high-risk outpatients with COVID-19. We sought to determine the real-world effectiveness of bebtelovimab during Omicron phases BA.2/BA2.12.1/BA4/BA5.

Methods

We conducted a retrospective cohort study of adults with SARS-CoV-2 infection between April 6 to October 11, 2022, using health records linked to vaccine and mortality data. We used propensity scores to match of bebtelovimab-treated with untreated outpatients. The primary outcome was 28-day all-cause hospitalization. Secondary outcomes were 28-day COVID-19-related hospitalization, 28-day all-cause mortality, 28-day ED visits, maximum respiratory support level, ICU admission, and in-hospital mortality among hospitalized patients. We used logistic regression to determine bebtelovimab treatment effectiveness.

Results

Among 22,720 patients with SARS-COV-2 infection, 3,739 bebtelovimab-treated patients were matched to 5,423 untreated patients. Compared to no treatment, bebtelovimab was associated with lower odds of 28-day all-cause hospitalization (1.3% vs. 2.1%, adjusted odds ratio (aOR): 0.53 [95%CI 0.37-0.74], p <0.001) as well as COVID-19 related hospitalization (1.0% vs. 2.0%, aOR:0.44 [95%CI 0.30-0.64], p <0.001). Bebtelovimab appeared more beneficial in lowering the odds of hospitalization among patients with two or more comorbidities (interaction p=0.03).

Conclusions

During the Omicron BA.2/BA.2.12.1/BA.4/BA.5 variant phase, bebtelovimab was associated with lower hospitalization.

SUBMITTER: Molina KC

PROVIDER: S-EPMC10106116 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Real-world evaluation of bebtelovimab effectiveness during the period of COVID-19 Omicron variants, including BA.4/BA.5.

Molina Kyle C KC Kennerley Victoria V Beaty Laurel E LE Bennett Tellen D TD Carlson Nichole E NE Mayer David A DA Peers Jennifer L JL Russell Seth S Wynia Matthew K MK Aggarwal Neil R NR Ginde Adit A AA

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20230416

<h4>Objectives</h4>Bebtelovimab is an anti-SARS-CoV-2 monoclonal antibody active against Omicron lineage variants authorized to treat high-risk outpatients with COVID-19. We sought to determine the real-world effectiveness of bebtelovimab during the Omicron phases BA.2/BA2.12.1/BA4/BA5.<h4>Methods</h4>We conducted a retrospective cohort study of adults with SARS-CoV-2 infection between April 6 and October 11, 2022, using health records linked to vaccine and mortality data. We used propensity sco ...[more]

PMID: 37072054

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