DOK3 promotes proliferation and inhibits apoptosis of prostate cancer via the NF-κB signaling pathway.

ABSTRACT:

Background

DOK3 (Downstream of kinase 3) is involved primarily with immune cell infiltration. Recent research reported the role of DOK3 in tumor progression, with opposite effects in lung cancer and gliomas; however, its role in prostate cancer (PCa) remains elusive. This study aimed to explore the role of DOK3 in PCa and to determine the mechanisms involved.

Methods

To investigate the functions and mechanisms of DOK3 in PCa, we performed bioinformatic and biofunctional analyses. Samples from patients with PCa were collected from West China Hospital, and 46 were selected for the final correlation analysis. A lentivirus-based short hairpin ribonucleic acid (shRNA) carrier was established for silencing DOK3. A series of experiments involving the cell counting kit-8, bromodeoxy

SUBMITTER: Jin K 

PROVIDER: S-EPMC10106266 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature