Causal pathways to social and occupational functioning in the first episode of schizophrenia: uncovering unmet treatment needs.

ABSTRACT:

Background

We aimed to identify unmet treatment needs for improving social and occupational functioning in early schizophrenia using a data-driven causal discovery analysis.

Methods

Demographic, clinical, and psychosocial measures were obtained for 276 participants from the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) trial at baseline and 6-months, along with measures of social and occupational functioning from the Quality of Life Scale. The Greedy Fast Causal Inference algorithm was used to learn a partial ancestral graph modeling causal relationships across baseline variables and 6-month functioning. Effect sizes were estimated using a structural equation model. Results were validated in an independent dataset (N = 187).

Re

SUBMITTER: Miley K 

PROVIDER: S-EPMC10106305 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature